Protein Details: Potassium voltage-gated channel subfamily S member 1
Protein ID
ICDB_Pro_0279
Protein Name
Potassium voltage-gated channel subfamily S member 1
Gene Name
Kcns1
Organism
Rattus norvegicus (Rat)
Length
497 amino acids
AlphaFoldDB
AF-O88758-F1-model_v4.pdb
Function
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2
Sequence
MVSEFPGPGSRVPWRPRDEALRVNVGGVRRLLSARALARFPGTRLGRLQAAVSEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLERRVTRPRAWDEDSDAPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEDVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDRRGASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEEKNVGFDTIPACWWWGTVSMTTVGYGDVVPETVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRSSGQREFEDLLSSVDGVSDVSLETSRETSQEGRSTDLETQAPSEPAKSHSY
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Highly expressed in brain; but not in the other tissues tested (PubMed:9704029).
DOI ID
10.1006/bbrc.1998.9072
RefSeq
NP_446406.1; XP_006235571.1; XP_017446922.1